[Harmonisation of validation strategies and estimation of the associated uncertainty in the framework of assay laboratoires accreditation]. / Harmonisation des stratégies de validation et estimation de l'incertitude associée dans le cadre de l'accreditation des laboratoires d'essais.

ABSTRACT

In order to achieve the harmonization of validation strategies, the interpretation of several validation criteria is proposed. Furthermore, a simple and visual decision tool to assess the validity of an analytical procedure is described the accuracy profile based on the estimation of the total error of the measurements. This profile build with beta-expectation tolerance intervals can also compute with efficiency the uncertainty related to the results of a laboratory, which is an essential parameter for the accreditation of laboratories under ISO 17025.