N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists.
Bioorg Med Chem Lett
; 16(22): 5748-51, 2006 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-16950620
A new class of potent NK3R antagonists based on the N',2-diphenylquinoline-4-carbohydrazide core is described. In an ex vivo assay in gerbil, the lead compound 2g occupies receptors within the CNS following oral dosing (Occ(90) 30 mg/kg po; plasma Occ(90) 0.95 microM) and has good selectivity and promising PK properties.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinolinas
/
Receptores da Neurocinina-3
/
Neurotransmissores
/
Hidrazinas
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2006
Tipo de documento:
Article
