Immune dysfunction in HIV-seronegative, Cryptococcus gattii meningitis.
J Infect
; 54(3): e165-8, 2007 Mar.
Article
em En
| MEDLINE
| ID: mdl-17109966
ABSTRACT
The pathophysiology of meningitis caused by Cryptococcus gattii in apparently immunocompetent individuals remains unclear. We measured multiple cytokines in CSF from a HIV-seronegative, apparently immunocompetent, Thai patient with C. gattii meningitis, over the first 2 weeks of antifungal therapy. Levels of proinflammatory IFN-gamma, TNF-alpha, and IL-6 were very low compared to patients with HIV-related Cryptococcus neoformans meningitis and of IL-10 very high. While patients with C. gattii meningitis may be a heterogeneous group, these data suggest in this case a maladapted immune response to cryptococcal exposure had allowed progression to clinical cryptococcal disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
3_ND
Problema de saúde:
3_neglected_diseases
/
3_zoonosis
Assunto principal:
Citocinas
/
Meningite Criptocócica
/
Cryptococcus
/
Meningite
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
J Infect
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Reino Unido