Effects of various cations on the dynamic and thermodynamics of the dimerization of G-quadruplex DNA.

ABSTRACT

DNA fragment, d(TTAGGG), forms all-parallel G-quadruplex in the presence of K(+).(1) We found that G-quadruplex d(TTAGGG) dimerizes through end-to-end stacking of the 3'-terminal G-quartets.(2) In this study, we report the effects of Mg(2+) and Ca(2+) on the dynamics and thermodynamics of the dimerization.