[Regulation of apoptosis in aggressive fibroblasts]. / Regulation des programmierten Zelltod in aggressiven Fibroblasten.
Z Rheumatol
; 66(3): 239-40, 242, 2007 May.
Article
em De
| MEDLINE
| ID: mdl-17436005
ABSTRACT
Apoptosis is a central physiological mechanism for maintaining cellular stability in tissue. Synovial fibroblasts, which play a central role in the pathogenesis of rheumatoid arthritis (RA), show a resistance to apoptosis. Several molecular mechanisms are involved in such resistance. Thus, soluble Fas can bind Fas ligands (Fas-L) and hinder Fas-L induced apoptosis in fibroblasts. SUMO-1 (a small ubiquitin-like modifier) attaches to proteins post-translationally. This appears to be significantly involved in apoptosis resistance in RA fibroblasts. SUMO-1 levels are substantially increased in synovial fibroblasts from RA patients. A change in the post-translational SUMOlation pattern could represent a new target for changing the stable activation of synovial fibroblasts in RA.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Membrana Sinovial
/
Apoptose
/
Modelos Imunológicos
/
Proteína SUMO-1
/
Fibroblastos
Limite:
Animals
/
Humans
Idioma:
De
Revista:
Z Rheumatol
Ano de publicação:
2007
Tipo de documento:
Article