Risedronate has no adverse effects on mouse haematopoiesis.
Folia Biol (Praha)
; 53(4): 143-5, 2007.
Article
em En
| MEDLINE
| ID: mdl-17706020
ABSTRACT
Bisphosphonates are commonly used for treatment of osteoporosis. They inhibit osteoclast activity and thus bone resorption. It was shown that they also affect some other cell types including tumour and endothelial cells. The effects of risedronate on bone marrow microenvironment were not studied yet. As endothelial cells are integral part of bone marrow microenvironment, it is important to know whether prolonged administration of bisphosphonates does not affect haematopoietic stem cells and bone marrow haematopoiesis. We fed mice two weeks with risedronate. We found no effect of risedronate treatment on bone marrow stem cells using the method of congenic bone marrow repopulation. Risedronate administration in the dose which is considered to be comparable to a dose of risedronate used for treatment of osteoporosis in women seems to be safe in terms of effects on mouse haematopoiesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Etidrônico
/
Conservadores da Densidade Óssea
/
Hematopoese
Limite:
Animals
Idioma:
En
Revista:
Folia Biol (Praha)
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
República Tcheca