Improved synthesis of mestranol and ethinyl estradiol (EE) related degradation products as authentic references.
Steroids
; 73(5): 488-94, 2008 May.
Article
em En
| MEDLINE
| ID: mdl-18255111
ABSTRACT
Preparative chemical methods for the synthesis of 10 degradation or photodecomposition products of mestranol and ethinyl estradiol (EE) are described. The synthesized compounds are useful as reference materials and standards for pharmaceutical analysis of mestranol and EE as bulk chemical or in formulated product. New synthetic methods were presented and the known synthetic procedures were improved. Detailed structural characterization of the degradation or photodecomposition products of mestranol and EE and related compounds was reported.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estrogênios
/
Etinilestradiol
/
Mestranol
Idioma:
En
Revista:
Steroids
Ano de publicação:
2008
Tipo de documento:
Article