Effects of sub-anesthetic doses of ketamine on rats' spatial and non-spatial recognition memory.
Neuroscience
; 154(2): 454-60, 2008 Jun 23.
Article
em En
| MEDLINE
| ID: mdl-18472348
ABSTRACT
There are experimental evidences indicating that the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist ketamine impairs cognition and produces a series of schizophrenia-like symptoms in rodents (hyperactivity, stereotypies and ataxia). The present study was designed to investigate the effects of ketamine on rats' non-spatial and spatial recognition memory. For this purpose the object recognition and the object location task were selected. Pre- or post-training systemic administration of ketamine (0.3, 1 and 3 mg/kg; i.p.) in a dose-dependent manner disrupted animals' performance in both these recognition memory paradigms, suggesting that this compound affected pre- and post-training memory components. The current results indicate that the non-competitive NMDA antagonist ketamine may modulate either spatial or non-spatial recognition memory.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Percepção Espacial
/
Antagonistas de Aminoácidos Excitatórios
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Reconhecimento Psicológico
/
Ketamina
/
Anestésicos Dissociativos
/
Memória
Limite:
Animals
Idioma:
En
Revista:
Neuroscience
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Grécia