Fed-batch culture of Bacillus thuringiensis for thuringiensin production in a tower type bioreactor.
Biotechnol Bioeng
; 48(3): 207-13, 1995 Nov 05.
Article
em En
| MEDLINE
| ID: mdl-18623480
ABSTRACT
Fed-batch culture of Bacillus thuringiensis in a modified airlift reactor has been developed by using adaptive control of glucose concentration in the reactor. The glucose concentration was estimated via a correlation equation between carbon dioxide production rate and glucose consumption rate. The estimated glucose concentration as the output variable was fed back to computer for calculation of substrate addition. The modified reactor was an airlift reactor with a net draft tube. The airlift reactor had high oxygen transfer rate and low shear stress which were important factors for production of thuringiensin. Fed-batch culture of Bacillus thuringiensis in the modified airlift reactor provided significant improvement of thuringiensin production.
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MEDLINE
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En
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Biotechnol Bioeng
Ano de publicação:
1995
Tipo de documento:
Article