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K-complex-induced seizures in autosomal dominant nocturnal frontal lobe epilepsy.
El Helou, J; Navarro, V; Depienne, C; Fedirko, E; LeGuern, E; Baulac, M; An-Gourfinkel, I; Adam, C.
Afiliação
  • El Helou J; AP-HP, Epileptology Unit, Neurology 1 Department, La Pitié-Salpêtrière Hospital, Paris, France.
Clin Neurophysiol ; 119(10): 2201-4, 2008 Oct.
Article em En | MEDLINE | ID: mdl-18762450
ABSTRACT

OBJECTIVE:

To examine in detail the relations between seizures and K-complexes in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE).

METHODS:

Prolonged continuous video-EEG recording and analysis of 30 seizures in an 18-year-old woman suffering from ADNFLE with a CHRNA4 gene mutation.

RESULTS:

Twenty-seven of 30 recorded seizures started just after a K-complex. In nine cases a sound induced a K-complex that was immediately followed by the seizure. Most seizures preceded repetitive and brief ictal restarts.

CONCLUSIONS:

Three new characteristics have been observed in this ADNFLE patient a K-complex is almost invariably present at seizure onset; sounds trigger some seizures; ictal restarts occur often.

SIGNIFICANCE:

These new observations--the presence of K-complexes at seizure onset and occurrence of sound-triggered seizures--support the view that ADNFLE seizures may be initiated by K-complexes.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ritmo Circadiano / Epilepsia do Lobo Frontal / Eletroencefalografia / Genes Dominantes Limite: Adolescent / Female / Humans Idioma: En Revista: Clin Neurophysiol Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ritmo Circadiano / Epilepsia do Lobo Frontal / Eletroencefalografia / Genes Dominantes Limite: Adolescent / Female / Humans Idioma: En Revista: Clin Neurophysiol Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: França
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