Diffusion tensor MR imaging evaluation of the corpus callosum of patients with multiple sclerosis.
Arq Neuropsiquiatr
; 66(3A): 449-53, 2008 Sep.
Article
em En
| MEDLINE
| ID: mdl-18813697
ABSTRACT
OBJECTIVE:
To evaluate the fractional anisotropy (FA) values of the normal-appearing white matter of the corpus callosum (CC) in patients with relapsing-remitting multiple sclerosis (MS).METHOD:
Fifty-seven patients with diagnosis of relapsing-remitting MS and 47 age- and gender-matched controls were studied. A conventional MR imaging protocol and a DTI sequence were performed. One neuroradiologist placed the regions of interest (ROIs) in the FA maps in five different portions of the normal-appearing CC (rostrum, genu, anterior and posterior portion of the body and splenium) in all cases. The statistical analysis was performed with the Mann-Whitney U test and p<0.05 was considered statistically significant.RESULTS:
The FA values were lower in the MS patients compared with the controls (p<0.05) in the following CC regions rostrum (0.720 vs 0.819), anterior body (0.698 vs 0.752), posterior body (0.711 vs 0.759) and splenium (0.720 vs 0.880).CONCLUSION:
In this series, there was a robust decrease in the FA in all regions of the normal-appearing CC, being significant in the rostrum, body and splenium. This finding suggests that there is a subtle and diffuse abnormality in the CC, which could be probably related to myelin content loss, axonal damage and gliosis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Corpo Caloso
/
Esclerose Múltipla Recidivante-Remitente
/
Imagem de Difusão por Ressonância Magnética
Tipo de estudo:
Guideline
/
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Arq Neuropsiquiatr
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Brasil