Kinetic resolution of racemic alcohols using thioamide modified 1-methyl-histidine methyl ester.
J Org Chem
; 73(21): 8558-62, 2008 Nov 07.
Article
em En
| MEDLINE
| ID: mdl-18844413
ABSTRACT
The low-molecular-weight and easily prepared N-thiobenzoyl 1-methyl-histidine methyl ester 3k was utilized to efficiently catalyze the kinetic resolution of racemic secondary alcohols. Comparison of the conformations of amide catalyst 3c and thioamide catalyst 3k was made to understand the origin of the improvement of the enantioselectivity by thioamide modification.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tioamidas
/
Álcoois
/
Histidina
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2008
Tipo de documento:
Article