[Reactivity of five different antibodies with benign and malignant melanocytic lesions]. / A különbözo antitestek reaktivitása benignus és malignus melanocitás daganatokban.
Magy Onkol
; 52(4): 363-73, 2008 Dec.
Article
em Hu
| MEDLINE
| ID: mdl-19068464
ABSTRACT
At the histological examination of an increasing number of melanocytic tumors there is a need to use various immunohistochemical methods. Currently, we are supplied by several antibodies working well on formalin-fixed, paraffin-embedded samples. We have tested five antibodies (S-100, HMB-45, Melan-A, MITF, PNL-2) on 34 benign and 34 malignant melanocytic tumors. We examined the specificity and sensitivity in the junctional and dermal component separately, with special consideration to features disturbing the evaluation (regression, halo-like inflammation, etc.). We have concluded that the histological diagnosis of melanocytic tumors is based on the detailed examination of traditional HE slides and the immunohistochemical methods only confirm or weaken our opinion.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Imuno-Histoquímica
/
Biomarcadores Tumorais
/
Melanoma
/
Antígenos de Neoplasias
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Proteínas de Neoplasias
/
Nevo
Limite:
Humans
Idioma:
Hu
Revista:
Magy Onkol
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2008
Tipo de documento:
Article