Mucosal muscarinic receptors enhance bladder activity in cats with feline interstitial cystitis.
J Urol
; 181(3): 1415-22, 2009 Mar.
Article
em En
| MEDLINE
| ID: mdl-19157447
ABSTRACT
PURPOSE:
Interstitial cystitis is a chronic pelvic pain syndrome of which the origin and mechanisms involved remain unclear. In this study Ca(2+) transients in the bladder wall of domestic cats diagnosed with naturally occurring feline interstitial cystitis were examined. MATERIALS ANDMETHODS:
Cross-sections of full-thickness bladder strips from normal cats and cats with feline interstitial cystitis were examined by optically mapping Ca(2+) transients and recording tension. Responses of Ca(2+) activity and detrusor contractions to pharmacological interventions were compared. In addition, pharmacological responses were compared in mucosa denuded preparations.RESULTS:
Optical mapping showed that feline interstitial cystitis bladders had significantly more spontaneous Ca(2+) transients in the mucosal layer than control bladders. Optical mapping also demonstrated that feline interstitial cystitis bladders were hypersensitive to a low dose (50 nM) of the muscarinic receptor agonist arecaidine when the mucosal layer was intact. This hypersensitivity was markedly decreased in mucosa denuded bladder strips.CONCLUSIONS:
In feline interstitial cystitis cat bladders there is increased Ca(2+) activity and sensitivity of muscarinic receptors in the mucosal layer, which can enhance smooth muscle spontaneous contractions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bexiga Urinária
/
Doenças do Gato
/
Receptores Muscarínicos
/
Cistite Intersticial
Limite:
Animals
Idioma:
En
Revista:
J Urol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos