Corticosteroid elimination in simultaneous liver-kidney transplantation recipients.
Clin Transplant
; 23(6): 958-63, 2009.
Article
em En
| MEDLINE
| ID: mdl-19664017
ABSTRACT
BACKGROUND:
Simultaneous liver-kidney transplantation (SLK) has more than doubled since 2002. While less common in kidney transplant alone recipients (KTA), corticosteroid discontinuation is performed routinely in liver transplantation, raising the question of optimal immunosuppression for SLK recipients.METHODS:
A retrospective case series of 16 SLK recipients under a steroid withdrawal protocol was performed to compare short-term outcomes to a contemporaneous cohort of 32 KTA recipients.RESULTS:
In 69% of SLK recipients, corticosteroids were eliminated compared to 3% of KTA recipients, p < 0.0001. When comparing SLK and KTA recipients one yr post-transplant, there were no significant differences in renal graft rejection (23.1% vs. 6.3%), death-censored renal graft survival (100% vs. 97%), estimated glomerular filtration rate (74.4 vs. 62.6 mL/min), serum creatinine (1.10 vs. 1.39 mg/dL), or maintenance immunosuppression, respectively.CONCLUSIONS:
Corticosteroids may be withdrawn safely in SLK recipients with one-yr renal outcomes comparable to a KTA cohort.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Problema de saúde:
6_digestive_diseases
/
6_kidney_renal_pelvis_ureter_cancer
Assunto principal:
Terapia de Imunossupressão
/
Transplante de Rim
/
Transplante de Fígado
/
Glucocorticoides
/
Rejeição de Enxerto
/
Imunossupressores
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Transplant
Assunto da revista:
TRANSPLANTE
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos