Interstitial pneumonitis in the transplant patient: consider sirolimus-associated pulmonary toxicity.
J La State Med Soc
; 161(3): 166, 168-72, 2009.
Article
em En
| MEDLINE
| ID: mdl-19772040
ABSTRACT
Interstitial pneumonia in a transplant patient can have a varied etiology. Sirolimus (Rapamycin; Rapamune) is a popularly used immunosuppressant in solid organ transplantation that has anecdotally been associated with pulmonary toxicity. Sirolimus-induced pulmonary toxicity consists of a range of syndromes that is characterized by the presence of organizing pneumonia, interstitial pneumonitis, pulmonary alveolar proteinosis, focal fibrosis, or by the presence of alveolar hemorrhage. Diagnosis can be challenging and is usually made by exclusion of other etiologies. In this report we present two cases of sirolimus-associated pulmonary toxicity with a review of the literature.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
4_TD
Problema de saúde:
4_pneumonia
Assunto principal:
Doenças Pulmonares Intersticiais
/
Sirolimo
/
Rejeição de Enxerto
/
Imunossupressores
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J La State Med Soc
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos