Chemical constituents of Nauclea latifolia and their anti-GST and anti-fungal activities.
Nat Prod Commun
; 4(9): 1185-8, 2009 Sep.
Article
em En
| MEDLINE
| ID: mdl-19831025
ABSTRACT
The crude ethanolic extract of Nauclea latifolia yielded five known compounds, strictosamide (1), naucleamides A (2), naucleamide F (3), quinovic acid-3-O-beta-rhamnosylpyranoside (4), and quinovic acid 3-O-beta-fucosylpyranoside (5). Microbial reactions, using a whole cell culture of Rhizopus circinans on compound (1), yielded three analogues, 10-hydroxystrictosamide (6), 10-beta-glucosyloxyvincoside lactam (7) and 16,17-dihydro-10-beta-glucosyloxyvincoside lactam (8). Compounds 1-8 were identified with the aid of extensive NMR spectral studies. Compound 8 was found to be a new metabolite. Compounds 1-8 exhibited different levels of anti-GST and anti-fungal activities.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rhizopus
/
Carbolinas
/
Extratos Vegetais
/
Rubiaceae
/
Inibidores Enzimáticos
/
Glutationa Transferase
/
Antifúngicos
Idioma:
En
Revista:
Nat Prod Commun
Assunto da revista:
BOTANICA
/
FARMACOLOGIA
/
QUIMICA
Ano de publicação:
2009
Tipo de documento:
Article