Serum YKL-40 levels in patients with ovarian cancer and women with BRCA1 gene mutation--comparison to CA 125 antigen.
Eur J Gynaecol Oncol
; 30(6): 668-71, 2009.
Article
em En
| MEDLINE
| ID: mdl-20099501
ABSTRACT
PURPOSE OF INVESTIGATION Our work was undertaken to determine the usefulness ofYKL-40 as a tumor marker in patients with ovarian cancer and women with BRCA 1 gene mutations. METHODS:
Our study population consisted of 111 patients. They were divided into five study groups I--newly diagnosed ovarian caner, II--recurrence of ovarian cancer, III--complete remission, IV--benign epithelial tumors and V--patients with BRCA 1 gene mutations. YKL-40 and CA 125 were determined in patient sera.RESULTS:
YKL-40 in newly diagnosed ovarian cancer patients was significantly higher (181.17 n/ml) than in patients with BRCA 1 gene mutation (97.74 ng/ml, p < 0.01), women with benign epithelial cancer (57.19 ng/ml, p < 0.005) and patients with ovarian cancer at the time of complete remission (58.12 ng/ml, p < 0.005). Taking 124 ng/ml as a cut-off value for YKL-40 (95th percentile for healthly women) we observed higher levels in 50% of patients from group I and in 38% from group II.CONCLUSIONS:
YKL-40 appears to demonstrate no advantage over CA 125 as a biomarker of ovarian cancer, particularly in women with early-stage tumors. More research is needed on carriers of the BRCA 1 gene muation in view of the elevated YKL-40 concentrations in this group.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Glicoproteínas
/
Biomarcadores Tumorais
/
Antígeno Ca-125
/
Genes BRCA1
/
Lectinas
Tipo de estudo:
Observational_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Eur J Gynaecol Oncol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Polônia