Single nucleotide polymorphisms and haplotypes of TLR6 gene in Chinese Cantonese population.
Int J Immunogenet
; 37(4): 245-51, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-20402822
ABSTRACT
Sequence polymorphisms in the coding region of Toll-like receptor 6 gene were investigated in Chinese Cantonese population. By amplifying and sequencing a 2787 bp segment containing the entire coding region of TLR6 gene of 191 individuals in Chinese Cantonese population, a total of seven single nucleotide polymorphisms (SNP) along with their frequencies were detected. Comparing these data with SNP published in dbSNP database of National Center for Biotechnology Information (NCBI), two SNP (+176T/C and +1408G/T) were firstly reported, and five SNP caused amino-acid substitution. Sixteen haplotypes and their distributions were reconstructed. Linkage disequilibrium analysis and neutrality test were also performed. Comparing with other ethnic populations, Chinese Cantonese displayed obvious differences in TLR6 polymorphism. It may in part reflect the ethnic diversity of pathogen susceptibility and facilitate to develop the disease-association studies as well as population genetics and evolutionary research.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Haplótipos
/
Etnicidade
/
Polimorfismo de Nucleotídeo Único
/
Povo Asiático
/
Receptor 6 Toll-Like
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Int J Immunogenet
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
GENETICA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
China