[Normal tissue tolerance to external beam radiation therapy: spinal cord]. / Tolérance à l'irradiation des tissus sains: moelle épinière.
Cancer Radiother
; 14(4-5): 269-76, 2010 Jul.
Article
em Fr
| MEDLINE
| ID: mdl-20561809
ABSTRACT
Radiation myelopathy is one of the most dreadful complications of radiation therapy. Despite multiple animal experiments and human autopsic series, its pathogenesis remains largely unknown. In most instances, the classical aspect of myelomalacy combines glial and vascular injuries in various sequences. Recent studies point out the role of oligodendrocytes and their precusors, as well as of intercellular mediators (cytokines and stress molecules). The clinical presentation comprises a spectrum of non specific neurological symptoms whose evolution is sometimes regressive but more commonly progressive and life-threatening. Usually, it occurs following a latent period of six months to two years after irradiation of the cervical, thoracic or upper lumbar spine to a dose in excess of 50 Gy, conventionally fractionated. Nonetheless, these typical features can be altered by extrinsic factors, such as hypofractionation/acceleration of the dose, multiple surgical procedures, chemotherapy especially megatherapy, or neurotoxic drugs. Conversely, hyperfractionated regimens that take into account protracted half-time repair of sublethal damages to the CNS, as well as sophisticated estimates of the dose to the cord and QA programs during the treatment course minimize such risks.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lesões por Radiação
/
Tolerância a Radiação
/
Radioterapia
/
Medula Espinal
/
Anormalidades Induzidas por Radiação
/
Doenças do Sistema Nervoso
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
Fr
Revista:
Cancer Radiother
Assunto da revista:
NEOPLASIAS
/
RADIOTERAPIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
França