The insulin sensitivity response is determined by the interaction between the G972R polymorphism of the insulin receptor substrate 1 gene and dietary fat.
Mol Nutr Food Res
; 55(2): 328-35, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-20824664
ABSTRACT
SCOPE Insulin resistance, a condition associated with type 2 diabetes mellitus, results from the interaction of environmental and genetic factors. The aim of this study was to explore the influence of the G972R polymorphism at the insulin receptor substrate 1 gene on insulin sensitivity in a healthy young population. Furthermore, we examined whether the presence of this single nucleotide polymorphism (SNP; GR or GG) interacts with dietary fat to modulate insulin sensitivity. METHODS AND RESULTS:
Fifty-nine healthy volunteers consumed three diets during 4 wk each following a randomized crossoverdesign:
a saturated fatty acid diet, a low-fat and high carbohydrate (CHO) diet or a MUFA diet. For each diet, we investigated peripheral insulin sensitivity with the insulin suppression test. Steady-state plasma glucose and plasma-free fatty acids concentrations were significantly lower in GR subjects after the intake of a CHO diet, than did homozygous GG subjects (p<0.05). However, no differences were observed after consuming the two other diets.CONCLUSIONS:
Insulin sensitivity increased in GR subjects for the G972R polymorphism at the insulin receptor substrate 1 gene locus, after intake of a CHO diet. Increased knowledge of how these and other genes influence insulin sensitivity should increase the understanding of personalized nutrition.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resistência à Insulina
/
Gorduras na Dieta
/
Polimorfismo de Nucleotídeo Único
/
Proteínas Substratos do Receptor de Insulina
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Mol Nutr Food Res
Assunto da revista:
CIENCIAS DA NUTRICAO
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Espanha