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Potential mechanisms by which polyphenol-rich grapes prevent obesity-mediated inflammation and metabolic diseases.
Chuang, Chia-Chi; McIntosh, Michael K.
Afiliação
  • Chuang CC; Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27402, USA. c_chuan2@uncg.edu
Annu Rev Nutr ; 31: 155-76, 2011 Aug 21.
Article em En | MEDLINE | ID: mdl-21548775
ABSTRACT
Obesity and metabolic disease-related health problems (e.g., type 2 diabetes, atherosclerosis, and hypertension) are the most prevalent nutrition-related issues in the United States. An emerging feature of obesity and type 2 diabetes is their linkage with chronic inflammation that begins in white adipose tissue and eventually becomes systemic. One potential strategy to reduce inflammation and insulin resistance is consumption of polyphenol-rich foods like grapes or their by-products, which have anti-inflammatory properties. Polyphenols commonly found in grape products have been reported to reduce inflammation by (a) acting as an antioxidant or increasing antioxidant gene or protein expression, (b) attenuating endoplasmic reticulum stress signaling, (c) blocking proinflammatory cytokines or endotoxin-mediated kinases and transcription factors involved in metabolic disease, (d) suppressing inflammatory- or inducing metabolic-gene expression via increasing histone deacetylase activity, or (e) activating transcription factors that antagonize chronic inflammation. Thus, polyphenol-rich grape products may reduce obesity-mediated chronic inflammation by multiple mechanisms, thereby preventing metabolic diseases.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitis / Polifenóis / Frutas / Doenças Metabólicas / Obesidade Limite: Animals / Humans Idioma: En Revista: Annu Rev Nutr Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitis / Polifenóis / Frutas / Doenças Metabólicas / Obesidade Limite: Animals / Humans Idioma: En Revista: Annu Rev Nutr Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos
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