Respiratory function in patients with pemphigus vulgaris - a small clinical study.
J Dermatol Case Rep
; 5(1): 1-4, 2011 Mar 26.
Article
em En
| MEDLINE
| ID: mdl-21886757
ABSTRACT
BACKGROUND:
Pemphigus vulgaris belongs to a group of rare, autoimmune, blistering disorders, requiring intensive immunosuppressive therapy. Lung infections are common in patients with pemphigus vulgaris.OBJECTIVE:
To evaluate pulmonary function in patients with pemphigus vulgaris, in order to detect possible factors that might predispose PV patients to lung damage.METHODS:
Ten patients first diagnosed with severe pemphigus vulgaris and 10 healthy individuals,were included in the study. Pulmonary function testing, blood gas analysis and quantification of α1-antitrypsin serum levels were performed.RESULTS:
Mild reduction of CO diffusing capacity was recorded, compared to the mean predicted normal value. DLCOSB (single-breath carbon monoxide diffusing capacity test) values did not significantly differ between patients with pemphigus vulgaris and healthy controls, while differences regarding DLCO/VA (VA Alveolar Volume) were statistically significant. Alpha 1-antitrypsin serum levels were decreased (<2.0g/L) in 60% (6/10) of patients with pemphigus vulgaris and were found normal in none of the healthy controls.CONCLUSION:
A mild reduction of pulmonary diffusing capacity was observed in patients with pemphigus vulgaris.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
J Dermatol Case Rep
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Grécia