Synthesis and anti-bacterial activity of some heterocyclic chalcone derivatives bearing thiofuran, furan, and quinoline moieties.
Arch Pharm (Weinheim)
; 344(10): 689-95, 2011 Oct.
Article
em En
| MEDLINE
| ID: mdl-21887800
ABSTRACT
36 Novel heterocyclic chalcone derivatives were synthesized and tested for their anti-bacterial activity. Some compounds presented good anti-microbial activities against Gram-positive bacteria (including the multidrug-resistant clinical isolates). This class of compounds presented high potency against Streptococcus mutans, among which the derivatives F2 with an MIC of 2 µg/mL was as active as the standard drug (norfloxacin) and less active than oxacillin. All the compounds did not inhibit the growth of Gram-negative bacteria (Escherichia coli CCARM 1924 or Escherichia coli CCARM 1356) at 64 µg/mL.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinolinas
/
Compostos de Enxofre
/
Desenho de Fármacos
/
Chalcona
/
Furanos
/
Antibacterianos
Idioma:
En
Revista:
Arch Pharm (Weinheim)
Ano de publicação:
2011
Tipo de documento:
Article