Cholera-like enterotoxins and Regulatory T cells.
Toxins (Basel)
; 2(7): 1774-95, 2010 07.
Article
em En
| MEDLINE
| ID: mdl-22069660
ABSTRACT
Cholera toxin (CT) and the heat-labile enterotoxin of E. coli (LT), as well as their non toxic mutants, are potent mucosal adjuvants of immunization eliciting mucosal and systemic responses against unrelated co-administered antigens in experimental models and in humans (non toxic mutants). These enterotoxins are composed of two subunits, the A subunit, responsible for an ADP-ribosyl transferase activity and the B subunit, responsible for cell binding. Paradoxically, whereas the whole toxins have adjuvant properties, the B subunits of CT (CTB) and of LT (LTB) have been shown to induce antigen specific tolerance when administered mucosally with antigens in experimental models as well as, recently, in humans, making them an attractive strategy to prevent or treat autoimmune or allergic disorders. Immunomodulation is a complex process involving many cell types notably antigen presenting cells and regulatory T cells (Tregs). In this review, we focus on Treg cells and cholera-like enterotoxins and their non toxic derivates, with regard to subtype, in vivo/in vitro effects and possible role in the modulation of immune responses to coadministered antigens.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
3_ND
Problema de saúde:
3_cholera
/
3_neglected_diseases
Assunto principal:
Toxinas Bacterianas
/
Toxina da Cólera
/
Linfócitos T Reguladores
/
Proteínas de Escherichia coli
/
Enterotoxinas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Toxins (Basel)
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
França