Expression of protein kinase C isoforms in cancerous breast tissue and adjacent normal breast tissue.
Chin J Physiol
; 55(1): 55-61, 2012 Feb 29.
Article
em En
| MEDLINE
| ID: mdl-22242955
ABSTRACT
The role of protein kinase C (PKC) in the carcinogenesis of human breast tissue has been studied at the molecular level for more than two decades. In this study, we employed Western blotting to determine the presence of PKC isoforms in cancerous and normal breast tissues. The results indicate significant expression of a conventional PKC (PKCα) and two atypical PKCs (PKC ζ and λ/ι) in both breast tumors and adjacent normal breast tissue. For the α,ζ and λ/ι isoforms, the expression of individual isoforms was higher in the breast tumors than in the adjacent normal breast tissue. Although the correlation coefficient was low, significant linear correlation was found among the activities of the isoforms. The data suggest a potential new direction in cancer chemotherapy, namely the blockage of the signal transduction pathway of specific PKC isoforms.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteína Quinase C
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Neoplasias da Mama
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Carcinoma Ductal de Mama
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Chin J Physiol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China