Topical cis-urocanic acid attenuates oedema and erythema in acute and subacute skin inflammation in the mouse.
Br J Dermatol
; 167(3): 506-13, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-22540389
ABSTRACT
BACKGROUND:
cis-Urocanic acid (cis-UCA) is an endogenous immunosuppressive molecule of the epidermis.OBJECTIVES:
We investigated the effects of topical cis-UCA creams (2·5% and 5%) in acute and subacute mouse models of skin inflammation.METHODS:
Acute skin irritation was induced by applying dimethyl sulphoxide (DMSO) on the earlobe of CD-1 mice. Topical cis-UCA, hydrocortisone (1%) or tacrolimus (0·1%) were applied 10 min later. In another model, subacute inflammation was provoked and maintained by three applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the ears of NMRI mice on days 1, 2 and 4. The test products were applied topically twice a day during 6 days.RESULTS:
In the acute DMSO model, cis-UCA creams suppressed ear swelling at 1 h significantly more efficiently than hydrocortisone (P < 0·01) and tacrolimus (P < 0·001). Ear swelling was significantly inhibited by cis-UCA (P < 0·001) in the subacute TPA model as well. The 5% cream also decreased erythema, whereas tacrolimus enhanced skin reddening. Treatments with cis-UCA did not affect TPA-induced infiltration of neutrophils to the skin. In contrast to hydrocortisone, cis-UCA did not reduce epidermal thickness.CONCLUSIONS:
The results suggest that cis-UCA - unlike hydrocortisone and tacrolimus - is efficient in both acute and subacute skin inflammation, attenuating skin oedema and erythema. Topical drug therapy with cis-UCA may provide a safe and effective drug treatment modality in inflammatory skin disorders.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Urocânico
/
Toxidermias
/
Fármacos Dermatológicos
/
Edema
/
Eritema
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Br J Dermatol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Finlândia