Attenuation of collagen-induced arthritis by orally available imidazoline-based NF-κB inhibitors.
Bioorg Med Chem Lett
; 22(14): 4816-9, 2012 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-22682057
ABSTRACT
The pathogenesis of rheumatoid arthritis is mainly driven by NF-κB-mediated production of cytokines, such as TNF-α. We report herein that the orally available imidazoline-based NF-κB inhibitor, TCH-013, was found to significantly reduce TNF-α signaling and attenuate collagen antibody induced arthritis in BALB/c mice.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Experimental
/
NF-kappa B
/
Imidazolinas
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos