Establishment of a monitoring system to detect inhibition of mRNA processing.
Biosci Biotechnol Biochem
; 76(6): 1248-51, 2012.
Article
em En
| MEDLINE
| ID: mdl-22790958
ABSTRACT
A number of proteins complete mRNA processing in the nucleus, thus, inhibitor of mRNA processing is worth finding to analyze the mechanism of mRNA maturation in detail. Here, we established a monitoring system for mRNA processing using a test compound, spliceostatin A (SSA), which inhibits mRNA splicing. This system should serve to facilitate the discovery of novel compounds from natural resources that inhibit mRNA processing.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piranos
/
Compostos de Espiro
/
Bioensaio
/
RNA Mensageiro
/
Núcleo Celular
/
Splicing de RNA
Limite:
Humans
Idioma:
En
Revista:
Biosci Biotechnol Biochem
Assunto da revista:
BIOQUIMICA
/
BIOTECNOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Japão
