Enantioselective oxidation of aldehydes catalyzed by alcohol dehydrogenase.

Könst, Paul; Merkens, Hedda; Kara, Selin; Kochius, Svenja; Vogel, Andreas; Zuhse, Ralf; Holtmann, Dirk; Arends, Isabel W C E; Hollmann, Frank

Könst, Paul; Merkens, Hedda; Kara, Selin; Kochius, Svenja; Vogel, Andreas; Zuhse, Ralf; Holtmann, Dirk; Arends, Isabel W C E; Hollmann, Frank.

Afiliação

Könst P; Department of Biotechnology, Delft University of Technology, Delft, The Netherlands.

Angew Chem Int Ed Engl ; 51(39): 9914-7, 2012 Sep 24.

Article em En | MEDLINE | ID: mdl-22936647

ABSTRACT

ABSTRACT

Teaching old dogs new tricks Alcohol dehydrogenases (ADHs) may be established redox biocatalysts but they still are good for a few surprises. ADHs can be used to oxidize aldehydes, and this was demonstrated by the oxidative dynamic kinetic resolution of profens. In the presence of a suitable cofactor regeneration system, this reaction can occur with high selectivity.

Assuntos

Álcool Desidrogenase/metabolismo; Aldeídos/metabolismo; Escherichia coli/enzimologia; Álcool Desidrogenase/genética; Álcoois/metabolismo; Escherichia coli/genética; Cinética; Lactobacillus/enzimologia; Oxirredução; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Estereoisomerismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 3_ND Problema de saúde: 3_neglected_diseases / 3_zoonosis Assunto principal: Álcool Desidrogenase / Aldeídos / Escherichia coli Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Holanda

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