Cross-sectional microhardness of bovine enamel subjected to three paediatric liquid oral medicines: an in vitro study.
Eur Arch Paediatr Dent
; 13(5): 261-5, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-23043884
ABSTRACT
AIM:
This study aimed to investigate the in vitro effects of three paediatric liquid oral medicines on bovine dental enamel subsurfaces under pH cycling conditions.METHODS:
Bovine enamel blocks were evaluated for surface hardness at baseline for sample selection. 52 intact bovine enamel blocks (16mm(2)) were randomly divided into four groups (n=13) according to the immersion treatments G1 antibiotic (Klaricid®), G2 antihistamine (Claritin®), G3 antihistamine (Dimetapp®) and G4 control (de-ionised water). The blocks were submitted to pH cycling treatments twice a day for 12 days. The medicines were evaluated for pH, viscosity, and concentration of calcium, phosphate and fluoride. After the treatment period, cross-sectional microhardness (CSMH) measurements of the enamel blocks were taken and the data, expressed in Knoop hardness number (kg/mm(2)) was used to calculate the ΔS. STATISTICS ANOVA followed by the Tukey test were used for statistical analyses (p<0.05).RESULTS:
The antibiotic Klaricid® showed the highest concentration of fluoride, calcium and phosphate. Considering pH and viscosity, the following pattern was observed according to the treatment group G4>G1>G2>G3 and G1>G2>G3>G4 respectively. Regarding the demineralisation pattern, the following results were observed G4>G3>G2>G1. Compared to the control, the antibiotic and both the antihistamines provoked less demineralisation of the enamel blocks (p<0.05).CONCLUSIONS:
Antibiotic G1 (Klaricid®) presented an in vitro protective effect against acid attacks probably due to its mineral content and viscosity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Excipientes Farmacêuticos
/
Esmalte Dentário
Tipo de estudo:
Prevalence_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Eur Arch Paediatr Dent
Assunto da revista:
ODONTOLOGIA
/
PEDIATRIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Brasil