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Common variant at 16p11.2 conferring risk of psychosis.
Steinberg, S; de Jong, S; Mattheisen, M; Costas, J; Demontis, D; Jamain, S; Pietiläinen, O P H; Lin, K; Papiol, S; Huttenlocher, J; Sigurdsson, E; Vassos, E; Giegling, I; Breuer, R; Fraser, G; Walker, N; Melle, I; Djurovic, S; Agartz, I; Tuulio-Henriksson, A; Suvisaari, J; Lönnqvist, J; Paunio, T; Olsen, L; Hansen, T; Ingason, A; Pirinen, M; Strengman, E; Hougaard, D M; Orntoft, T; Didriksen, M; Hollegaard, M V; Nordentoft, M; Abramova, L; Kaleda, V; Arrojo, M; Sanjuán, J; Arango, C; Etain, B; Bellivier, F; Méary, A; Schürhoff, F; Szoke, A; Ribolsi, M; Magni, V; Siracusano, A; Sperling, S; Rossner, M; Christiansen, C; Kiemeney, L A.
Afiliação
  • Steinberg S; deCODE genetics, Reykjavik, Iceland.
  • de Jong S; Center for Neurobehavioral Genetics, UCLA, Los Angeles, CA, USA.
  • Mattheisen M; 1] Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Institute for Genomic Mathematics, University of Bonn, Bonn, Germany [3] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
  • Costas J; Galician Foundation of Genomic Medicine-SERGAS, Complexo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, Spain.
  • Demontis D; 1] Department of Biomedicine, Human Genetics, and Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark [2] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
  • Jamain S; 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France.
  • Pietiläinen OP; 1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland [3] Wellcome Trust Sanger Institute, Cambridge, UK.
  • Lin K; Department of Neuroscience, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King's College, London, UK.
  • Papiol S; 1] DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany [2] Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
  • Huttenlocher J; 1] deCODE genetics, Reykjavik, Iceland [2] Department of Medical Genetics, Institute of Human Genetics, University of Tübingen, Tübingen, Germany.
  • Sigurdsson E; 1] Department of Psychiatry, National University Hospital, Reykjavik, Iceland [2] School of Medicine, University of Iceland, Reykjavik, Iceland.
  • Vassos E; Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK.
  • Giegling I; Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany.
  • Breuer R; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
  • Fraser G; Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen, UK.
  • Walker N; Ravenscraig Hospital, Greenock, UK.
  • Melle I; Division of Mental Health and Addiction, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway.
  • Djurovic S; Division of Mental Health and Addiction, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway.
  • Agartz I; Division of Mental Health and Addiction, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway.
  • Tuulio-Henriksson A; Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
  • Suvisaari J; Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
  • Lönnqvist J; Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
  • Paunio T; Public Health Genomics Unit, National Institute for Health and Welfare THL, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
  • Olsen L; Institute of Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University, Roskilde, Denmark.
  • Hansen T; Institute of Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University, Roskilde, Denmark.
  • Ingason A; Institute of Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University, Roskilde, Denmark.
  • Pirinen M; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Strengman E; Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands.
  • Hougaard DM; Section of Neonatal Screening and Hormones, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen, Denmark.
  • Orntoft T; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.
  • Didriksen M; Synaptic transmission, H. Lundbeck A/S, Copenhagen, Denmark.
  • Hollegaard MV; Section of Neonatal Screening and Hormones, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen, Denmark.
  • Nordentoft M; 1] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [2] Psychiatric Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.
  • Abramova L; Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
  • Kaleda V; Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
  • Arrojo M; Service of Psychiatry, Complexo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, Spain.
  • Sanjuán J; Unit of Psychiatry, Faculty of Medicine, University of Valencia, Network Center of Biomedical Research on Mental Health (CIBERSAM), Valencia, Spain.
  • Arango C; Hospital General Universitario Gregorio Marañón, IiSGM, Universidad Complutense, CIBERSAM, Madrid, Spain.
  • Etain B; 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France.
  • Bellivier F; 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France [4] Université Paris Est, Faculté de Médecine, Creteil, France.
  • Méary A; 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France.
  • Schürhoff F; 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France [4] Université Paris Est, Faculté de Médecine, Creteil, France.
  • Szoke A; 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France.
  • Ribolsi M; Section of Psychiatry, Department of Neuroscience, University of Rome-Tor Vergata, Rome, Italy.
  • Magni V; Section of Psychiatry, Department of Neuroscience, University of Rome-Tor Vergata, Rome, Italy.
  • Siracusano A; Section of Psychiatry, Department of Neuroscience, University of Rome-Tor Vergata, Rome, Italy.
  • Sperling S; Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
  • Rossner M; 1] DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany [2] Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
  • Christiansen C; Nordic Bioscience, Herlev, Denmark.
  • Kiemeney LA; Department of Epidemiology and Biostatistics and Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Mol Psychiatry ; 19(1): 108-14, 2014 Jan.
Article em En | MEDLINE | ID: mdl-23164818
ABSTRACT
Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18 206 cases and 42 536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46 160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T]; odds ratio=1.08; P=6.6 × 10(-11)). The new variant is located within a 593-kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (P=0.0039 in the public GIANT consortium data set; P=0.00047 in 22 651 additional Icelanders).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Transtorno Bipolar / Cromossomos Humanos Par 16 / Aberrações Cromossômicas / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único Tipo de estudo: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Mol Psychiatry Assunto da revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Islândia
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Transtorno Bipolar / Cromossomos Humanos Par 16 / Aberrações Cromossômicas / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único Tipo de estudo: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Mol Psychiatry Assunto da revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Islândia