Translational control by 3'-UTR-binding proteins.
Brief Funct Genomics
; 12(1): 58-65, 2013 Jan.
Article
em En
| MEDLINE
| ID: mdl-23196851
ABSTRACT
The regulation of mRNA translation is a major checkpoint in the flux of information from the transcriptome to the proteome. Critical for translational control are the trans-acting factors, RNA-binding proteins (RBPs) and small RNAs that bind to the mRNA and modify its translatability. This review summarizes the mechanisms by which RBPs regulate mRNA translation, with special focus on those binding to the 3'-untranslated region. It also discusses how recent high-throughput technologies are revealing exquisite layers of complexity and are helping to untangle translational regulation at a genome-wide scale.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biossíntese de Proteínas
/
Proteínas de Ligação a RNA
/
Regiões 3' não Traduzidas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Brief Funct Genomics
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Espanha