Evidence of a systemic predisposition to chondrocalcinosis and association between chondrocalcinosis and osteoarthritis at distant joints: a cross-sectional study.
Arthritis Care Res (Hoboken)
; 65(7): 1052-8, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23335553
ABSTRACT
OBJECTIVE:
To determine whether there is a systemic predisposition to chondrocalcinosis (CC) and to examine the association between CC and osteoarthritis (OA) at distant joints.METHODS:
We performed a cross-sectional study embedded in the Genetics of Osteoarthritis and Lifestyle (GOAL) database (n = 3,170). All GOAL participants have had radiographs of the knees, hands, and pelvis performed. These were scored for OA at the knee, hip, wrist, and metacarpophalangeal (MCP) joints and for CC at the knee, hip, wrist, and symphysis pubis joints and for MCP joint calcification. Systemic predisposition to CC was established using cluster analysis. Odds ratios (95% confidence intervals) were used to examine the association between CC at the index and distant joints, CC and OA at the same joint, and index joint OA and distant joint CC. We adjusted for age, sex, and body mass index, and for distant joint OA, if required.RESULTS:
Joints with CC clustered together. This was also observed when participants with OA were excluded from the analysis. CC at each joint was associated with CC at distant joints. Knee and wrist OA but not hip OA was associated with CC at the same joint. MCP joint OA was associated with MCP joint calcification. Knee OA was associated with CC at other joints, and this was independent of OA at the distant joint. There was no association between hip OA and distant joint CC.CONCLUSION:
There is a systemic predisposition to the apparently sporadic CC. OA is associated with CC at the same joint and at distant joints, except hip OA, which is not associated with hip CC or with CC at distant joints.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoartrite do Quadril
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Condrocalcinose
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Osteoartrite do Joelho
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Arthritis Care Res (Hoboken)
Assunto da revista:
REUMATOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Reino Unido