Tracking cells in their native habitat: lineage tracing in epithelial neoplasia.
Nat Rev Cancer
; 13(3): 161-71, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23388619
ABSTRACT
For tumours to develop, mutations must disrupt tissue homeostasis in favour of deregulated proliferation. Genetic lineage tracing has uncovered the behaviour of proliferating cells that underpins the maintenance of epithelial tissues and the barriers that are broken in neoplastic transformation. In this Review, we focus on new insights revealed by quantifying the behaviour of normal, preneoplastic and tumour cells in epithelia in transgenic mice and consider their potential importance in humans.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transformação Celular Neoplásica
/
Neoplasias Epiteliais e Glandulares
/
Linhagem da Célula
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Rastreamento de Células
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Cancer
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Reino Unido