In vitro and in vivo model systems for studying enteropathogenic Escherichia coli infections.
Cold Spring Harb Perspect Med
; 3(3): a009977, 2013 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-23457294
ABSTRACT
Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) belong to a group of bacteria known as attaching and effacing (A/E) pathogens that cause disease by adhering to the lumenal surfaces of their host's intestinal epithelium. EPEC and EHEC are major causes of infectious diarrhea that result in significant childhood morbidity and mortality worldwide. Recent advances in in vitro and in vivo modeling of these pathogens have contributed to our knowledge of how EPEC and EHEC attach to host cells and subvert host-cell signaling pathways to promote infection and cause disease. A more detailed understanding of how these pathogenic microbes infect their hosts and how the host responds to infection could ultimately lead to new therapeutic strategies to help control these significant enteric pathogens.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
2_ODS3
/
3_ND
/
4_TD
/
7_ODS3_muertes_prevenibles_nacidos_ninos
Problema de saúde:
2_enfermedades_transmissibles
/
2_muertes_prevenibles
/
3_diarrhea
/
3_neglected_diseases
/
3_zoonosis
/
4_diarrhoeal_infections
/
7_environmental_health
Assunto principal:
Infecções por Escherichia coli
/
Escherichia coli Enteropatogênica
/
Modelos Biológicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cold Spring Harb Perspect Med
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Canadá