[Nitric oxide pathway and female lower urinary tract. Physiological and pathophysiological role]. / Voie du monoxyde d'azote et bas appareil urinaire féminin. Rôles physiologique et physiopathologique.
Prog Urol
; 23(11): 926-35, 2013 Sep.
Article
em Fr
| MEDLINE
| ID: mdl-24010923
ABSTRACT
GOAL The aim was to review the literature on nitric oxide and female lower urinary tract. MATERIAL:
A literature review through the PubMed library until December, 31 2012 was carried out using the following keywords lower urinary tract, bladder, urethra, nervous central system, innervation, female, women, nitric oxide, phosphodiesterase, bladder outlet obstruction, urinary incontinence, overactive bladder, urinary tract infection.RESULTS:
Two nitric oxide synthase isoforms, the neuronal (nNOS) and the endothelial (eNOS), are constitutively expressed in the lower urinary tract. Nevertheless, nNOS is mainly expressed in the bladder neck and the urethra. In the bladder, NO modulates the afferent neurons activity. In pathological condition, inducible NOS expression induces an increase in detrusor contractility and bladder wall thickness and eNOS facilitates Escherichia coli bladder wall invasion inducing recurrent urinary tract infections. In the urethra, NO play a major role in smooth muscle cells relaxation.CONCLUSION:
The NO pathway plays a major role in the female lower urinary tract physiology and physiopathology. While it acts mainly on bladder outlet, in pathological condition, it is involved in bladder dysfunction occurrence.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Uretra
/
Bexiga Urinária
/
Transdução de Sinais
/
Óxido Nítrico Sintase Tipo I
/
Óxido Nítrico Sintase Tipo III
/
Óxido Nítrico
Limite:
Female
/
Humans
Idioma:
Fr
Revista:
Prog Urol
Assunto da revista:
UROLOGIA
Ano de publicação:
2013
Tipo de documento:
Article