Treatment of intractable anorexia nervosa with inactivation of the nucleus accumbens using stereotactic surgery.
Stereotact Funct Neurosurg
; 91(6): 364-72, 2013.
Article
em En
| MEDLINE
| ID: mdl-24108066
ABSTRACT
BACKGROUND:
For 30% of anorexia nervosa (AN) patients, conventional treatments are unsuccessful; this is termed intractable AN.OBJECTIVES:
This study investigates whether ablation of the nucleus accumbens (NAc) using stereotactic surgery can arouse the physiological drive to eat in intractable AN patients.METHODS:
Eight patients with intractable AN were included 6 patients underwent bilateral stereotactic radio frequency ablation in the NAc and 2 patients received bilateral NAc deep brain stimulation (DBS). Observations were made for basic vital signs, body mass index (BMI), menstruation, depression, anxiety, obsessive-compulsive disorder, personality, intelligence, memory, quality of life, social functioning, as well as complications and adverse events associated with the treatment.RESULTS:
Basic vital signs, BMI and menstruation had recovered 1 year after the operation. Depression, anxiety and obsessive-compulsive disorder were improved 1 year postoperatively. There were changes in personality scores for psychoticism, neuroticism and lie tendencies that seemed to be helpful to the recovery from AN. Intelligence and memory improved after 6 months postoperatively. Quality of life and social functioning were dramatically improved at 1 year postoperatively.CONCLUSIONS:
The results of this study reveal that ablation of the NAc can increase the AN patients' physiological drive to eat. Furthermore, there were no severe and/or life-influencing complications associated with the treatment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anorexia Nervosa
/
Técnicas Estereotáxicas
/
Estimulação Encefálica Profunda
/
Núcleo Accumbens
Aspecto:
Patient_preference
Limite:
Adolescent
/
Adult
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Female
/
Humans
Idioma:
En
Revista:
Stereotact Funct Neurosurg
Assunto da revista:
NEUROCIRURGIA
Ano de publicação:
2013
Tipo de documento:
Article