A role of FCER1A and FCER2 polymorphisms in IgE regulation.
Allergy
; 69(2): 231-6, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24354852
ABSTRACT
BACKGROUND:
Both FCER2 and FCER1A encode subunits of IgE receptors. Variants in FCER1A were previously identified as major determinants of IgE levels in genome-wide association studies.METHODS:
Here we investigated in detail whether FCER2 polymorphisms affect IgE levels alone and/or by interaction with FCER1A polymorphisms. To cover the genetic information of FCER2, 21 single-nucleotide polymorphisms (SNPs) were genotyped by Illumina HumanHap300 BeadChip (5 SNPs) and the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS; 14 SNPs) in at least 1303 Caucasian children (651 asthmatics) (ISAAC II/ MAGICS population); genotypes of two SNPs were imputed.RESULTS:
SNP rs3760687 showed the most consistent effect on total serum IgE levels (b [SE] = -0.38 [0.16]; P = 0.016), while FCER2 polymorphisms in general were predominantly associated with mildly-to-moderately increased IgE levels (50th and 66th percentiles). Gene-by-gene interaction analysis suggests that FCER2 polymorphism rs3760687 influences IgE levels mainly in individuals not homozygous for the risk allele of FCER1A polymorphism rs2427837, which belongs to the major IgE-determining tagging bin in the population.CONCLUSION:
FCER2 polymorphism rs3760687 affects moderately elevated total serum IgE levels, especially in the absence of homozygosity for the risk allele of FCER1A SNP rs2427837.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Imunoglobulina E
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Receptores de IgE
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
/
Lectinas Tipo C
Limite:
Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Allergy
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Alemanha