Mutagenesis of mitochondrial DNA in Fuchs endothelial corneal dystrophy.

Czarny, P; Seda, A; Wielgorski, M; Binczyk, E; Markiewicz, B; Kasprzak, E; Jiménez-García, M P; Grabska-Liberek, I; Pawlowska, E; Blasiak, J; Szaflik, J; Szaflik, J P

Czarny, P; Seda, A; Wielgorski, M; Binczyk, E; Markiewicz, B; Kasprzak, E; Jiménez-García, M P; Grabska-Liberek, I; Pawlowska, E; Blasiak, J; Szaflik, J; Szaflik, J P.

Afiliação

Czarny P; Department of Molecular Genetics, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Seda A; Department of Molecular Genetics, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Wielgorski M; Department of Ophthalmology, Medical University of Warsaw and Samodzielny Publiczny Kliniczny Szpital Okulistyczny, Sierakowskiego 13, 03-710 Warsaw, Poland.
Binczyk E; Department of Ophthalmology, Medical University of Warsaw and Samodzielny Publiczny Kliniczny Szpital Okulistyczny, Sierakowskiego 13, 03-710 Warsaw, Poland.
Markiewicz B; Department of Molecular Genetics, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Kasprzak E; Department of Molecular Genetics, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Jiménez-García MP; University of Málaga, Malaga, Spain.
Grabska-Liberek I; Warsaw Eye Bank, Al. Solidarnosci 67, 03-401 Warsaw, Poland; Ophthalmology Clinic, Medical Center of Postgraduate Education, ul. Czerniakowska 231, 00-416 Warsaw, Poland.
Pawlowska E; Department of Orthodontics, Medical University of Lodz, Pomorska 251, 92-216 Lodz, Poland.
Blasiak J; Department of Molecular Genetics, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Szaflik J; Department of Ophthalmology, Medical University of Warsaw and Samodzielny Publiczny Kliniczny Szpital Okulistyczny, Sierakowskiego 13, 03-710 Warsaw, Poland.
Szaflik JP; Department of Ophthalmology, Medical University of Warsaw and Samodzielny Publiczny Kliniczny Szpital Okulistyczny, Sierakowskiego 13, 03-710 Warsaw, Poland. Electronic address: szaflik@ophthalmology.pl.

Mutat Res ; 760: 42-7, 2014 Feb.

Article em En | MEDLINE | ID: mdl-24374226

Assuntos

DNA Mitocondrial/genética; Distrofia Endotelial de Fuchs/genética; Distrofia Endotelial de Fuchs/patologia; Mitocôndrias/patologia; Mutagênese; Idoso; Apoptose; Estudos de Casos e Controles; Variações do Número de Cópias de DNA; Dano ao DNA/genética; Reparo do DNA/genética; Feminino; Humanos; Peróxido de Hidrogênio/farmacologia; Masculino; Pessoa de Meia-Idade; Mitocôndrias/genética; Oxidantes/farmacologia; Estresse Oxidativo; Deleção de Sequência

Palavras-chave

4977bp mtDNA common deletion; AMD; AS-OCT; CD; CE; DM; Descemet membrane; ETC; FECD; Fuchs endothelial corneal dystrophy; IVCM; Oxidative stress; PBLs; PBS; ROS; SLR rt-PCR; age-related macular degeneration; anterior segment optical coherence tomography; common deletion; corneal endothelial; electron transport chain; in vivo confocal microscopy; mitochondrial DNA; mtDNA; mtDNA copy number; mtDNA damage and repair; peripheral blood lymphocytes; phosphate buffered saline; qPCR; quantitative PCR; reactive oxygen species; semi-long rt-PCR; tRNA; transfer RNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Distrofia Endotelial de Fuchs / Mutagênese / Mitocôndrias Tipo de estudo: Observational_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Mutat Res Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Polônia

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