Systems-based discovery of tomatidine as a natural small molecule inhibitor of skeletal muscle atrophy.

Dyle, Michael C; Ebert, Scott M; Cook, Daniel P; Kunkel, Steven D; Fox, Daniel K; Bongers, Kale S; Bullard, Steven A; Dierdorff, Jason M; Adams, Christopher M

Dyle, Michael C; Ebert, Scott M; Cook, Daniel P; Kunkel, Steven D; Fox, Daniel K; Bongers, Kale S; Bullard, Steven A; Dierdorff, Jason M; Adams, Christopher M.

Afiliação

Dyle MC; From the Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 and.
Ebert SM; From the Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 and.
Cook DP; From the Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 and.
Kunkel SD; From the Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 and.
Fox DK; From the Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 and.
Bongers KS; From the Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 and.
Bullard SA; From the Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 and the Iowa City Veterans Affairs Medical Center, Iowa City, Iowa 52
Dierdorff JM; From the Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 and.
Adams CM; From the Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 and the Iowa City Veterans Affairs Medical Center, Iowa City, Iowa 52

J Biol Chem ; 289(21): 14913-24, 2014 May 23.

Article em En | MEDLINE | ID: mdl-24719321

Assuntos

Fibras Musculares Esqueléticas/efeitos dos fármacos; Músculo Esquelético/efeitos dos fármacos; Atrofia Muscular/prevenção & controle; Tomatina/análogos & derivados; Animais; Linhagem Celular; Linhagem Celular Tumoral; Células Cultivadas; Descoberta de Drogas/métodos; Expressão Gênica/efeitos dos fármacos; Células HL-60; Humanos; Immunoblotting; Células MCF-7; Masculino; Alvo Mecanístico do Complexo 1 de Rapamicina; Camundongos; Camundongos Endogâmicos C57BL; Mitocôndrias Musculares/efeitos dos fármacos; Mitocôndrias Musculares/genética; Mitocôndrias Musculares/metabolismo; Complexos Multiproteicos/genética; Complexos Multiproteicos/metabolismo; Fibras Musculares Esqueléticas/citologia; Fibras Musculares Esqueléticas/metabolismo; Proteínas Musculares/genética; Proteínas Musculares/metabolismo; Músculo Esquelético/metabolismo; Músculo Esquelético/patologia; Atrofia Muscular/genética; Atrofia Muscular/metabolismo; Mioblastos Esqueléticos/citologia; Mioblastos Esqueléticos/efeitos dos fármacos; Mioblastos Esqueléticos/metabolismo; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Transdução de Sinais/efeitos dos fármacos; Serina-Treonina Quinases TOR/genética; Serina-Treonina Quinases TOR/metabolismo; Tomatina/farmacologia

Palavras-chave

Muscle Atrophy; Skeletal Muscle; Skeletal Muscle Metabolism; Systems Biology; Tomatidine; mTOR complex (mTORC)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tomatina / Atrofia Muscular / Músculo Esquelético / Fibras Musculares Esqueléticas Idioma: En Revista: J Biol Chem Ano de publicação: 2014 Tipo de documento: Article

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