Hyperglycemia promotes vasculogenesis in choroidal neovascularization in diabetic mice by stimulating VEGF and SDF-1 expression in retinal pigment epithelial cells.

Cai, Yan; Li, Xia; Wang, Yu-Sheng; Shi, Yuan-Yuan; Ye, Zi; Yang, Guo-Dong; Dou, Guo-Rui; Hou, Hui-Yuan; Yang, Nan; Cao, Xiao-Rui; Lu, Zi-Fan

Cai, Yan; Li, Xia; Wang, Yu-Sheng; Shi, Yuan-Yuan; Ye, Zi; Yang, Guo-Dong; Dou, Guo-Rui; Hou, Hui-Yuan; Yang, Nan; Cao, Xiao-Rui; Lu, Zi-Fan.

Afiliação

Cai Y; Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, 710032 Xi'an, Shaanxi Province, People's Republic of China.
Li X; Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, 710032 Xi'an, Shaanxi Province, People's Republic of China.
Wang YS; Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, 710032 Xi'an, Shaanxi Province, People's Republic of China. Electronic address: wangys003@126.com.
Shi YY; Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, 710032 Xi'an, Shaanxi Province, People's Republic of China.
Ye Z; Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, 710032 Xi'an, Shaanxi Province, People's Republic of China.
Yang GD; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, 710032 Xi'an, Shaanxi Province, People's Republic of China.
Dou GR; Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, 710032 Xi'an, Shaanxi Province, People's Republic of China.
Hou HY; Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, 710032 Xi'an, Shaanxi Province, People's Republic of China.
Yang N; Department of Orthodontics, School of Stomatology, Fourth Military Medical University, 710032 Xi'an, Shaanxi Province, People's Republic of China.
Cao XR; Department of Orthopedics, Xijing Hospital, Fourth Military Medical University, 710032 Xi'an, Shaanxi Province, People's Republic of China.
Lu ZF; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, 710032 Xi'an, Shaanxi Province, People's Republic of China. Electronic address: luzfliuq@fmmu.edu.cn.

Exp Eye Res ; 123: 87-96, 2014 Jun.

Article em En | MEDLINE | ID: mdl-24780853

Assuntos

Vasos Sanguíneos/fisiologia; Quimiocina CXCL12/metabolismo; Neovascularização de Coroide/metabolismo; Diabetes Mellitus Experimental/metabolismo; Hiperglicemia/metabolismo; Epitélio Pigmentado da Retina/metabolismo; Fator A de Crescimento do Endotélio Vascular/metabolismo; Animais; Glicemia/metabolismo; Células da Medula Óssea/patologia; Diferenciação Celular; Movimento Celular; Quimiocina CXCL12/genética; Neovascularização de Coroide/patologia; Técnicas de Cocultura; Ensaio de Imunoadsorção Enzimática; Técnica Indireta de Fluorescência para Anticorpo; Expressão Gênica; Proteínas de Fluorescência Verde/genética; Células-Tronco Hematopoéticas/patologia; Masculino; Células-Tronco Mesenquimais/patologia; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Reação em Cadeia da Polimerase em Tempo Real; Fator A de Crescimento do Endotélio Vascular/genética

Palavras-chave

age-related macular degeneration; bone marrow-derived cells; diabetes mellitus; retinal pigment epithelial cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasos Sanguíneos / Neovascularização de Coroide / Fator A de Crescimento do Endotélio Vascular / Diabetes Mellitus Experimental / Quimiocina CXCL12 / Epitélio Pigmentado da Retina / Hiperglicemia Limite: Animals Idioma: En Revista: Exp Eye Res Ano de publicação: 2014 Tipo de documento: Article

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