Hydrotrifluoromethylthiolation of α-diazo esters--synthesis of α-SCF3 substituted esters.

ABSTRACT

A practical protocol for hydrotrifluoromethylthiolation of diazo compounds has been developed. A range of diazo compounds in combination with a nucleophilic SCF3 source provided access to valuable trifluoromethylthiolated compounds. Furthermore, a methodology for the first double trifluoromethylthiolation was developed.