[Intracerebral HIV replication despite an efficient antiretroviral treatment: clinical impact and management]. / Réplication cérébrale du VIH malgré une thérapie antirétrovirale efficace: impact clinique et prise en charge.
Rev Med Suisse
; 10(427): 908, 910-2, 2014 Apr 23.
Article
em Fr
| MEDLINE
| ID: mdl-24843987
ABSTRACT
Various neurological and neuropsychological manifestations are still relatively frequently reported in HIV infected patients in the highly active antiretroviral therapy era. A fraction of them could be related to HIV replication in the central nervous system (CNS) despite adequate peripheral viral suppression. This hypothesis is supported by numerous reports of detectable HIV RNA in the cerebrospinal fluid in the context of a low or undetectable viremia in association with neurological or neuropsychological complaints. In addition, some antiviral molecules may not achieve adequate levels in the CNS, thus potentially favoring intracerebral HIV replication and even antiretroviral resistance. Neurologic manifestations in the presence of CNS HIV replication often decrease after antiretroviral treatment CNS penetration optimization.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
2_ODS3
Problema de saúde:
2_enfermedades_transmissibles
Assunto principal:
Replicação Viral
/
Encefalopatias
/
Infecções por HIV
Limite:
Humans
Idioma:
Fr
Revista:
Rev Med Suisse
Assunto da revista:
MEDICINA
Ano de publicação:
2014
Tipo de documento:
Article