Impact of maternal hyperlipidic hypercholesterolaemic diet on male reproductive organs and testosterone concentration in rabbits.
J Dev Orig Health Dis
; 5(3): 183-8, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24901657
ABSTRACT
The concept of Developmental Origins of Health and Disease initially stemmed from the developmental programming of metabolic diseases. Reproductive functions and fertility in adulthood may also be programmed during foetal development. We studied the impact of dietary-induced maternal hyperlipidaemia and hypercholesterolaemia (HH), administered at 10 weeks of age and throughout the gestation and lactation, on male reproductive functions of rabbit offspring. Male rabbits born to HH dams and fed a control diet had significantly lighter testes and epididymes compared with rabbits born to control dams at adulthood. No significant changes in sperm concentration, sperm DNA integrity and sperm membrane composition were observed, but serum-free testosterone concentrations were decreased in HH males. This study confirms the importance of maternal metabolic status for the development of male reproductive organs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espermatozoides
/
Testosterona
/
Fenômenos Fisiológicos da Nutrição Pré-Natal
/
Genitália Masculina
/
Hipercolesterolemia
/
Hiperlipidemias
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
J Dev Orig Health Dis
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
França