Relationship of osteopontin and renal function with severity of coronary artery lesions.
Int J Clin Exp Med
; 7(4): 1122-7, 2014.
Article
em En
| MEDLINE
| ID: mdl-24955193
ABSTRACT
AIM:
To explore the relationship of plasma osteopontin (OPN) level and renal function with severity of coronary artery lesions.METHODS:
OPN level and renal function were detected and compared in 210 patients with coronary heart disease (CHD group) and 134 patients without coronary heart disease (control group) to analyze the relationship of osteopontin and renal function with severity of coronary artery lesions.RESULTS:
Plasma OPN and creatinine level were significantly higher in CHD group than those in control group (P<0.01), and estimated glomerular filtration rate (eGFR) was lower in CHD group than that in control group (P<0.01). The proportions of multi-vessel lesion and moderate to severe decreased renal function were higher in patients with high osteopontin than those in patients with low osteopontin (P<0.05), and the proportion of multi-vessel lesion was higher in patients with moderate to severe decreased renal function than that in normal renal function (P<0.05). Osteopontin and renal failure were the independent risk factors for coronary heart disease.CONCLUSIONS:
Plasma OPN level is associated with renal failure, both of which are correlated with the severity of coronary artery lesions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Revista:
Int J Clin Exp Med
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
China