2-Chlorobenzylidene malonitrile (CS) causes spindle disturbances in V79 Chinese hamster cells.
Mutat Res
; 226(2): 133-6, 1989 Jun.
Article
em En
| MEDLINE
| ID: mdl-2499783
ABSTRACT
Exposure of V79 Chinese hamster cells to 2-chlorobenzylidene malonitrile (CS), a chemical used as a sensory irritant for riot control, caused a concentration-dependent increase in the incidence of spindle disturbances. A C-mitotic effect with the appearance of C-metaphases, a metaphase block and the concomitant disappearance of ana-telophase figures were observed after a 3-h treatment. The results indicate that CS might induce aneuploidy in mammalian cells by interacting with the mitotic apparatus.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
O-Clorobenzilidenomalonitrila
/
Mitose
/
Fuso Acromático
/
Nitrilas
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Mutat Res
Ano de publicação:
1989
Tipo de documento:
Article