Effects of short-term oral administration of trimethoprim-sulfamethoxazole on tear production in clinically normal Syrian hamsters.
Vet Ophthalmol
; 18(1): 83-5, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25273510
ABSTRACT
OBJECTIVE:
To determine effects of 14 days of oral administration of trimethoprim-sulfamethoxazole on aqueous tear production in clinically normal Syrian hamsters. ANIMAL STUDIED Fifteen healthy adult Syrian hamsters. PROCEDURE Baseline phenol red thread test (PRTT) values were recorded 1 day prior to treatment. Eight hamsters in treated group received 15 mg/kg trimethoprim-sulfamethoxazole orally twice a day for 14 days. The remaining seven hamsters were used as untreated controls and received a placebo. All ophthalmic tests were performed without chemical restraint. PRTT values were evaluated in both eyes of all Syrian hamsters using a commercial PRTT strip of a single lot number.RESULTS:
The mean ± SD baseline PRTT values for treatment group and control group were 7.25 ± 1.3 mm/15 s and 5.42 ± 1.13 mm/15 s, respectively. After 14 days of drug administration, the mean ± SD PRTT values for treatment group and control group were 5.62 ± 1.5 and 5.64 ± 0.74, respectively. Significant decreases in the PRTT values, compared with baseline values, were observed in the treatment group on day 15 (P = 0.042).CONCLUSIONS:
Trimethoprim-sulfamethoxazole decreased tear production in the hamster in this study.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lágrimas
/
Combinação Trimetoprima e Sulfametoxazol
/
Anti-Infecciosos
Limite:
Animals
Idioma:
En
Revista:
Vet Ophthalmol
Assunto da revista:
MEDICINA VETERINARIA
/
OFTALMOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Irã