Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties.

Zhang, Yanmei; Tortorella, Micky D; Wang, Yican; Liu, Jianqi; Tu, Zhengchao; Liu, Xiaorong; Bai, Yang; Wen, Dingsheng; Lu, Xin; Lu, Yongzhi; Talley, John J

Zhang, Yanmei; Tortorella, Micky D; Wang, Yican; Liu, Jianqi; Tu, Zhengchao; Liu, Xiaorong; Bai, Yang; Wen, Dingsheng; Lu, Xin; Lu, Yongzhi; Talley, John J.

Afiliação

Zhang Y; Drug Discovery Pipeline, Guangzhou Institutes of Biomedicine and Health , Science City, Guangzhou 510530, P. R. China.
Tortorella MD; Drug Discovery Pipeline, Guangzhou Institutes of Biomedicine and Health , Science City, Guangzhou 510530, P. R. China.
Wang Y; Drug Discovery Pipeline, Guangzhou Institutes of Biomedicine and Health , Science City, Guangzhou 510530, P. R. China.
Liu J; Drug Discovery Pipeline, Guangzhou Institutes of Biomedicine and Health , Science City, Guangzhou 510530, P. R. China.
Tu Z; Drug Discovery Pipeline, Guangzhou Institutes of Biomedicine and Health , Science City, Guangzhou 510530, P. R. China.
Liu X; Drug Discovery Pipeline, Guangzhou Institutes of Biomedicine and Health , Science City, Guangzhou 510530, P. R. China.
Bai Y; Drug Discovery Pipeline, Guangzhou Institutes of Biomedicine and Health , Science City, Guangzhou 510530, P. R. China.
Wen D; Drug Discovery Pipeline, Guangzhou Institutes of Biomedicine and Health , Science City, Guangzhou 510530, P. R. China.
Lu X; Drug Discovery Pipeline, Guangzhou Institutes of Biomedicine and Health , Science City, Guangzhou 510530, P. R. China.
Lu Y; Drug Discovery Pipeline, Guangzhou Institutes of Biomedicine and Health , Science City, Guangzhou 510530, P. R. China.
Talley JJ; Department of Chemistry, St. Louis University , St. Louis, Missouri 63108, United States ; Euclises Pharmaceuticals, St. Louis, Missouri 63108, United States.

ACS Med Chem Lett ; 5(10): 1162-6, 2014 Oct 09.

Article em En | MEDLINE | ID: mdl-25313331

Palavras-chave

COX-2; NSAID; benzopyran; coxib; deuterium

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Med Chem Lett Ano de publicação: 2014 Tipo de documento: Article