Genetic and epidemiological insights into the emergence of peste des petits ruminants virus (PPRV) across Asia and Africa.
Sci Rep
; 4: 7040, 2014 Nov 13.
Article
em En
| MEDLINE
| ID: mdl-25391314
ABSTRACT
Small ruminants are important components in the livelihood of millions of households in many parts of the world. The spread of the highly contagious peste des petits ruminants (PPR) disease, which is caused by an RNA virus, PPRV, across Asia and Africa remains a major concern. The present study explored the evolutionary and epidemiological dynamics of PPRV through the analyses of partial N-gene and F-gene sequences of the virus. All the four previously described PPRV lineages (I-IV) diverged from their common ancestor during the late-19(th) to early-20(th) century. Among the four lineages, PPRV-IV showed pronounced genetic structuring across the region; however, haplotype sharing among the geographic regions, together with the presence of multiple genetic clusters within a country, indicates the possibility of frequent mobility of the diseased individuals across the region. The gradual decline in the effective number of infections suggests a limited genetic variation, which could be attributed to the effective vaccination that has been practiced since 1990s. However, the movement of infected animals across the region likely contributes to the spread of PPRV-IV. No evidence of positive selection was identified from this study.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
2_ODS3
Problema de saúde:
2_enfermedades_transmissibles
Assunto principal:
Filogenia
/
Proteínas Virais
/
Ruminantes
/
Vírus da Peste dos Pequenos Ruminantes
/
Peste dos Pequenos Ruminantes
/
Anticorpos Antivirais
Limite:
Animals
País/Região como assunto:
Africa
/
Asia
Idioma:
En
Revista:
Sci Rep
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos